WordPress 3.3 was officially released yesterday, Dec 12 2011, and it looks great! Read more about it here.
I’ve updated several of my own (including trotterWay.com) and my client’s sites, about 12 so far, without any issues. Just remember to make a backup first and note any plugin incompatibilities, though I didn’t find any with the ones I’m using.
Several plugin vendors and developers have released updates to their plugins so be sure to update those as well.

Passing WordPress URL Query String Parameters to Control Page Content
How to Highlight WordPress Authors in Search using the Genesis Framework
Changing Default Read More Link in Genesis Child Themes
Custom Genesis WordPress Sidebar





